VSEL Stem Cell Regenerative Treatments

For decades, science has pursued the dream of utilizing stem cells to develop anti-aging therapies, advance tissue repair, and treat everything from cancer to autoimmune diseases. To date, ethical, logistical, and safety issues have been the bottleneck to reaching that fountain of youth.

With advances in supplements, various peptide therapies, and lifestyle hacks, the evolving field of Biohacking and regenerative medicine is at the forefront of finding ways to look, feel, and live our very best. 

PRP (platelet-rich plasma) injections have gained enormous popularity in the aesthetic world due to various issues, including hair loss, wound healing, skin tightening, and wrinkle reduction. Drawing and isolating the plasma portion of our blood for reinjection into various skin parts can provide essential growth factors, cells, and signal mechanisms that may improve many aspects of aging skin. To date, although effective for some, these procedures have proven unpredictable in overall efficacy. Finally, we have catapulted into a future of promise with VSEL stem cell PRP therapy.


What are VSEL Stem Cell Regenerative Treatments?

The most exciting advancement to date in regenerative medicine is the discovery and application of VSEL cells (tiny embryonic-like stem cells), which have the ‘pluripotent’ ability to turn into various cells throughout the human body. These little cells, smaller than a blood cell, are present since embryogenesis and are found in all tissues, laying dormant throughout our lives until activated in stressful situations such as a heart attack. They are essentially  “backup” stem cells for repair. Unlike actual embryonic stem cells and ones that are experimentally reprogrammed from adult-developed cells, VSELs pose no ethical or safety risk (i.e., cancer promotion).

Over the past several years of published research, the scientific community has learned how to isolate them and how they work. With modern laser technology, they can harness their potential for health and aesthetic rejuvenation. A landmark study in heart failure patients statistically showed dramatic improvements in cardiac function with this cutting-edge VSEL infusion therapy. 

Dr. Paul Jarrod Frank is one of a small handful of physicians worldwide on the clinical advisory team with the developers of this patented laser technology. He collaborates with members of the scientific team from Johns Hopkins, which has studied these cells and created the protocols necessary to make VSEL treatments a clinical reality in medicine!


How Does VSEL Stem Cells Work?

Much like our extensive use of PRP over the years, we can now take these therapies to the next level. This is PRP 2.0! With direct injection into desired skin sites and IV infusion with external laser therapy, we can send VSEL stem cells directly to their preferred targets of inflammation and symptoms of aging. These combined working techniques from the inside and out exemplify all PFRANKMD Pro-Aging therapies, providing remarkable advances for cosmetic concerns only available at PFRANKMD


1. Extraction of PRP

The process begins by drawing a sample of the patient’s blood, similar to a standard blood test. The blood is then put in a centrifuge, which spins it at high speeds, causing it to separate into layers based on the density of its components. The Platelet Rich Plasma (PRP) layer is extracted because it’s rich in platelets, growth factors, and stem cells, including VSELs. 

2. Activation of VSELs Using Laser

Once the PRP is obtained, the next step involves activating the VSELs from their bound inactive components in the plasma. This is achieved by applying a patented photoreactive laser, a highly specialized and modulated diode laser technology, directly onto the PRP solution for several minutes. This laser light appears like visible red light, creates no heat, and has no carcinogenicity.

3. Administration of VSEL Treatment

After the VSELs have been isolated in the PRP solution, they are ready to be administered to the patient. This can be done through various methods depending on the area of the body that requires regeneration:

  • Intravenously (IV): For systemic or widespread effects, VSELs can be administered through an IV to circulate throughout the body and target areas that need regeneration.

  • Direct Injection: For localized treatment, such as hair follicles for hair loss or skin for wrinkles or scars, VSELs can be directly injected into these areas.

4. Laser-Guided Procedure

Once the VSELs are infused, the next step is to direct them to areas of desired regeneration. This involves using a specially calibrated laser to “guide” or “direct” the VSELs to the target areas in the body that require regeneration. The laser accomplishes this by creating a favorable or ‘sticky” environment for the VSELs to hone in on or activate them in a way that enhances their regenerative capabilities. The use of lasers in this context is touted to be painless and safe, even for sensitive areas like the eyes. No goggles are necessary. The laser guidance is usually performed 10 to 20 minutes after injection or infusion.

VSEL Stem Cell Treatments at PFRANKMD

The treatments using VSEL stem cells involve a sophisticated process of extracting, isolating, and administering these cells, augmented by cutting-edge laser technology to enhance their regenerative effects. 

VSEL Vitality Infusions

At PFRANKMD, we are performing VSEL PRP IV infusions using a 20-minute laser-guided protocol to target the main organs for age rejuvenation: the brain, eyes and ears, the pituitary, the thyroid, thymus, adrenal glands, and gonads. Patients note, within days to weeks, an increased sense of wellness and energy, improved sleep, immunity, and sexual function. 

VRG Fillers

In addition to the VSEL infusion therapy, we have developed a technique to turn VSEL-rich plasma into actual ‘fillers’ otherwise known as ‘VRG’ (VSEL-rich gels). We can use VRG to volumize tissue and improve wrinkles, fine lines, and crepey skin anywhere on the body without using foreign products. With the public’s increasing fear of commercial fillers, we can now avoid the unpredictable or allergenic potential associated with them. We are using your own “autologous” tissue. Safer, long-lasting, and naturally bio-stimulating, it is the rejuvenation we have always dreamed of in aesthetic medicine.  

VSEL Aquagold

Using the unique hollow bored gold needles of the Aquagold device, we can micro-needle laser-activated VSEL PRP into the skin, offering a more effective alternative to the “vampire facelift,” which has gained more traction on social media than as a proven therapy.

VSEL Recovery Infusions

Performed intravenously, VSEL is specifically laser-guided to the area of trauma. It is also helpful in recovering from any cosmetic procedure, whether laser resurfacing or plastic surgery. VSEL therapy can be used topically after treatment or intravenously to increase the speed of recovery and reverse advanced age. 

VSEL PRP for Hair Restoration

With VSEL hair restoration, we can replace traditional PRP therapy with platelet-rich plasma with stem cells for hair loss. VSEL hair restoration using stem cells offers significantly greater efficacy in stimulating hair growth by providing platelet growth factors and activated stem cells. 

We are now at the forefront of life extension and age reversal both physically and aesthetically, and as expected, you will find it here first at PFRANKMD.

Ideal Candidates

The ideal candidates for VSEL stem cell treatments, particularly those focused on anti-aging and regeneration, typically fall into specific categories based on their health status, conditions they might be facing, and their overall goals for treatment. However, it’s crucial to note that as this field is relatively new and rapidly evolving, criteria for candidacy might vary and should always be determined in consultation with Dr. Paul Jarrod Frank. Generally, potential ideal candidates may include:

1. Individuals Seeking Cosmetic and Anti-Aging Treatments:

People interested in reducing the signs of aging, improving skin quality, hair restoration, or other cosmetic enhancements might consider VSEL therapy. Its potential to regenerate tissue could translate into rejuvenated skin, reduced wrinkles, and improved hair density.

2. Individuals Looking for Age Reversal and regenerative Treatments:

Those interested in exploring cutting-edge regenerative therapies for overall wellness and vitality problems might be candidates for VSEL therapy. The multipotent nature of these cells offers a broad range of potential applications currently being studied for conditions such as ALS, Parkinson’s, macular degeneration, and a variety of orthopedic disabilities.

3. Individuals with Age-Related conditions:

In aging individuals facing conditions, VSEL therapy could enhance tissue repair, similarly aiding those with persistent injuries like non-healing wounds and joint issues where conventional treatments falter.

Schedule a Consultation

Ready to enhance your natural beauty and rejuvenate your appearance? Take the first step towards your aesthetic goals by booking a consultation for VSEL Stem Cell Regenerative Treatments. Contact PFRANKMD to schedule a consultation at our 5th Avenue or West Village location in NYC.

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Articles and Research


How do VSEL stem cells for hair differ from traditional PRP injections for hair growth?

VSEL stem cells for hair aim to leverage the regenerative potential of stem cells to repair and rejuvenate hair follicles, possibly offering a more fundamental restoration. In contrast, PRP injections focus on stimulating existing hair follicles and improving their health through growth factors contained in platelets. While PRP is more established and backed by a larger body of evidence, VSEL therapy represents a newer frontier in regenerative medicine with potentially broader implications for hair restoration. As with any medical treatment, individuals should consult with Dr. Frank to determine the most appropriate option based on their specific condition, needs, and the current state of research.

How is VSEL Stem Cell Therapy performed?

The therapy typically involves three main steps: extracting platelet-rich plasma (PRP) from the patient’s blood, isolating VSEL Stem Cells using a specialized technique with laser technology, and administering these cells back into the patient, either intravenously or through direct injections into specific areas needing regeneration. The laser is then used externally to guide the stem cells to their desired anatomic destination.

What conditions can VSEL Stem Cell Therapy potentially treat?

VSEL Stem Cell Therapy has potential applications in a wide range of conditions, including age-related degenerative diseases and chronic injuries, as well as for cosmetic and anti-aging purposes, such as skin rejuvenation and hair restoration.

Who are the ideal candidates for VSEL Stem Cell Therapy?

Ideal candidates may include individuals with age-related degenerative conditions, chronic injuries that have not responded to conventional treatments, those seeking cosmetic improvements, and those looking for alternative regenerative therapies.

How many treatments are needed?

The number of VSEL Stem Cell Therapy treatments required can vary significantly depending on several factors, including:

1. The Condition Being Treated: Certain conditions may respond more quickly to VSEL therapy, requiring fewer treatments, while others, particularly more severe or chronic conditions, might need multiple sessions to achieve desired results.

2. Treatment Goals: The specific objectives of the therapy (e.g., regeneration, repair, cosmetic improvement) can influence the number of treatments. For example, cosmetic applications require fewer sessions than treatments to repair tissue damage or manage chronic diseases.

3. Individual Response: Everybody responds differently to stem cell therapies. Factors such as age, overall health, lifestyle, and the body’s natural healing capabilities can impact the effectiveness of the treatment and, consequently, the number of sessions needed.

4. Treatment Protocol: The specific protocol followed, including the method of administration (intravenous vs. direct injection), dosage of stem cells, and adjunctive therapies used, can also affect the number of treatments required.

Are there any side effects associated with VSEL Stem Cell Therapy?

As with any medical procedure, there can be potential side effects. Compared to the cosmetic use of foreign agents, VSEL PRP is considered “autologous,” as it comes from our bodies. These may vary depending on the administration method, the treated condition, and the individual patient’s response. Common concerns could include infection at the injection site, immune reactions, or unintended effects on surrounding tissues.

How long does it take to see results from VSEL Stem Cell Therapy?

The time frame to see results can vary widely depending on the condition being treated, the severity of the condition, and individual patient factors. Some patients may notice improvements in a few days, while others may take several weeks to months to observe significant changes.

Do regulatory authorities approve VSEL Stem Cell Therapy?

The regulatory approval status of VSEL Stem Cell Therapy varies by country and the specific application of the therapy. Many treatments are still in the experimental or clinical trial phase and may not be widely approved for routine clinical use. As an advanced form of PRP, it is legal and ethical to perform it as autologous stem cells are used only.

How much does VSEL Stem Cell Therapy cost?

The cost of VSEL Stem Cell Therapy can vary significantly based on the treatment area, the number of sessions required, and geographic location. It’s essential to consult with treatment providers for detailed pricing and to understand what is included in the treatment package.